Cancer.
Test options before starting your treatment. In the lab. Without side effects.
Benefits of Reverse Clinical Engineerings®
Requirements for the Reverse Clinical Engineering®
The Reverse Clinical Engineering® test procedure can be used to determine the optimal drug therapy for patients with malignant solid tumors. This requires fresh tissue from a biopsy or resection. The procedure cannot be applied to blood cancers (leukemias) or lymphatic cancers (lymphomas).
Your contact persons
Clinical Liaison Management
You are not sure if Reverse Clinical Engineering® is suitable for you? Or you would like to learn more about our method? Contact us or arrange a consultation.
How does Reverse Clinical Engineering® work?
Personalized
We test anticancer therapies on your own tumor cells.
Targeted
We aim to find your cancer’s specific Achilles’ heel.
Automated
Robots allow us to test hundreds of drugs in parallel – rapidly and accurately.
Data-based
The data from your tumor is carefully analyzed and presented in a readily comprehensible way.
Extendable
Add-on options, such as sequencing or proteomic analysis, can further reinforce the treatment strategy.
Facts & Figures
Selected literature
- Boehnke, K. et al. Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures. J Biomol Screen 21, 931-41 (2016).
- Vlachogiannis, G. et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science 359, 920-926 (2018).
- Wensink, G.E. et al. Patient-derived organoids as a predictive biomarker for treatment response in cancer patients. npj Precis Onc 5, 30 (2021).
In addition to treatment options, ASC Oncology provided me with optimal support during a time of uncertainty and gave me new perspectives on my life with the disease. My oncologist implemented the recommended medication – with success!
Die neue Methode von ASC Oncology macht die Versorgung von Krebspatienten effektiv besser als alles, was die Medizin bisher kannte. Durch den personalisierten Ansatz wird die Lebensqualität und gleichzeitig die Überlebenschance jedes einzelnen Patienten signifikant erhöht. Von Anfang an können wir als Onkologen für unsere Patienten den Einsatz unwirksamer Medikamente vermeiden und direkt die aussichtsreichste Therapie empfehlen.
Collaborations
FAQ
We go one step further. Sequencing tumors, for example, can reveal changes in the genetic material that may be used as a target for treatment of your tumor. However, it’s not clear if the targeted treatment will work in your case. Recent studies have shown that only a fraction of patients (0.8 – 3%) have been able to benefit from a therapy chosen for its sequencing results (Tannock & Hickman, 2019). In contrast, ASC Oncology’s Reverse Clinical Engineering® uses a person’s own tumor model to directly test the cancer drugs’ efficacy. This allows a prediction to be made about how you will respond to therapy. Find out more about the test procedure under Science.
Your treating physician removes a small piece of cancer tissue during your surgery or biopsy and sends this directly to ASC Oncology’s laboratory. Our team of scientists multiplies the living tumor cells in the lab and grows “avatars” of your tumor, called ‘tumor organoids’. These avatars of the tumor can be used to test drugs that may be candidates for treating your tumor, allowing the most effective anticancer drug to be determined before therapy begins. Our results are an important decision-making aid for personalized anticancer therapy. Compared to following standard guideline recommended therapy, this approach has higher chances of treatment success. View a complete list of steps of the procedure here.
It varies. Depending on the quality of the tumor sample and the cancer entity, growing PD3D® tumor models can take different amounts of time. On average, the Reverse Clinical Engineering® test procedure takes 28 days from receiving the sample to preparing the final report.
Please do not send a sample without letting us know in advance. Please contact us at 0800 6988667 or use our online form to register a patient and send a sample. We will organize the pick-up and provide everything needed to transport it as quickly as possible – even for short-term requests. Take a look at our overview of the procedure.
ASC Oncology was founded in 2019 by leading scientists in the fields of pathology, biology, biochemistry, biotechnology, and tumor biology. We are an interdisciplinary team of experts, who together with lawyers and business information specialists, are dedicated in our fight against cancer and to advance precision oncology.
ASC Oncology benefits from years of expertise in 3D cell culture and the latest findings in the field of tumor organoid research through close collaboration with its sister company CELLphenomics, which was founded in 2014. In addition, we are supported by a top-class advisory board consisting of physicians, scientists, and patient representatives.
