Would you like to increase your chances of having an effective cancer therapy?

Together with your oncologist, we determine the effectiveness of various cancer drugs on your individual tumor before your therapy begins.

The Reverse Clinical Engineering®-test procedure

With Reverse Clinical Engineering®, ASC Oncology has developed a method that starts before your medical cancer therapy: a part of your tumor will be surgically removed. This tissue is then propagated in our laboratories as a cell culture in the Petri dish. We are now speaking of so-called tumor organoids or PD3D® cell cultures. The tumor organoids serve as small images of your individual tumor. We use them to test various medications and combinations to identify substances that are highly likely to affect your tumor. In addition, our test shows which drugs are likely to be ineffective, a valuable information that saves you the side effects of unnecessary therapies. Studies confirm that our test method correctly predicts the efficacy of drugs for a particular patient in around 88 % of cases and the ineffectiveness in up to 100 % of cases, (Vlachogiannis, 2018), thereby significantly prolonging disease-free survival.

The doctor’s decision about your therapy is by no means superfluous. However, through our test result your physician has a valuable support in selecting the optimal therapy for you. We support you as a patient with our dedication, experience and professional competence and support you through our network of clinics, universities and research institutes.

Who benefits from our test

Our test procedure is right for you:

You have been diagnosed with a solid tumor (a carcinoma or sarcoma).

Your tumor will be surgically removed, or a biopsy has been planned.

You will receive drug therapy.

Our test procedure is not right for you:

You have been diagnosed with blood cancer (leukemia) or lymphatic cancer (lymphoma).

Your tumor has already been removed, or a biopsy is not possible.

You will not receive a drug therapy.

Do you have questions or you are not sure if our test is suitable for you? Contact us via our contact form or by phone, we look forward to advise you.

Our next steps

  1. You have decided to take advantage of our service. In order to be able to coordinate everything with your oncologist, we first need a release from medical confidentiality from your side. You will receive these and all other required documents from us by email.
  1. As soon as we have received your order confirmation, we will send our sample tubes to an adress specified by you, for example to your home. You take these with you to the clinic for your surgery or biopsy appointment.
  1. During your tumor surgery or biopsy, your surgical team will place a small piece of your freshly removed tumor tissue into our sample tube and send it by express courier to our laboratories.
  1. We will send you notifications about the current status of your test. For example, we will inform you upon receipt of your tumor sample, at the beginning of the test and as soon as your results are available.
  1. We will send the final report to your oncologist, who can use the results for the selection of the optimal therapy and avoid ineffective medications. Take a look at our sample report to get an idea of what you can expect from us.
  1. Finally, you and your oncologist will arrange an appointment to discuss the results, if desired together with us.

For us it is very important to accompany both you and your oncologist on the way to a cancer therapy that is appropriate for you. We will take some steps with you, some with youroncologist and for some the team play between all of us is essential.

Costs

Developed by ASC, Reverse Clinical Engineering® supports oncologists in treating patients better and more effectively. Various studies have shown that the ASC method can reliably determine how effective the drugs will work, even before therapy begins. The PD3D® test procedure is, however, still one of the individual health services (known in Germany as IGeL) that must be paid by the patient privately. This means that you are charged the costs for this complex and labor-intensive procedure. We will create a personal offer for you that fits your needs and your individual situation.

PD3D®-Test
„Rudolf Virchow“

Creating a PD3D® cell culture from tumor tissue

We use a fresh sample taken from your tumor to create a 3D cell culture. This is done by multiplying the tumor cells in a petri dish. Potential active substances are then tested on the tumor.

Testing up to 4 cancer drugs

We consult with your oncologist to test the drugs that s/he believes are appropriate in your individual case and for your cancer.

A personal report for your doctor

After the agreed active substances have been successfully tested, we use modern software to evaluate the data. We then prepare a report for your doctor, which presents the data in a comprehensible way, and make specific suggestions for treatment – based on your individual tumor data.

PD3D®-Test
„Henrietta Lacks“

Creating a PD3D® cell culture from tumor tissue

We use a fresh sample taken from your tumor to create a 3D cell culture. This is done by multiplying the tumor cells in a petri dish. Potential active substances are then tested on the tumor.

Testing up to 8 cancer drugs; optionally with up to 4 therapy combinations.

Especially when the tumor disease is in an advanced stage, there is a greater choice of drugs available to treat your tumor than in patients undergoing initial treatment. That is why, to attack the tumor as effectively as possible, we test more drugs and combination therapies.

A personal report for your doctor

After the agreed active substances have been successfully tested, we use modern software to evaluate the data. We then prepare a report for your doctor, which presents the data in a comprehensible way, and make specific suggestions for treatment – based on your individual tumor data.

PD3D®-Test
„Mina Bissell“

Creating a PD3D® cell culture from tumor tissue

We use a fresh sample taken from your tumor to create a 3D cell culture. This is done by multiplying the tumor cells in a petri dish. Potential active substances are then tested on the tumor.

Testing up to 12 cancer drugs; optionally with up to 6 therapy combinations.

Especially when the tumor disease is in an advanced stage, there is a greater choice of drugs available to treat your tumor than in patients undergoing initial treatment. That is why, to attack the tumor as effectively as possible, we test more drugs and combination therapies.

A personal report for your doctor

After the agreed active substances have been successfully tested, we use modern software to evaluate the data. We then prepare a report for your doctor, which presents the data in a comprehensible way, and make specific suggestions for treatment – based on your individual tumor data.

Which test is the right one for me?

Our test packages differ in the number of tumor tissue samples processed, the range of drugs tested, the choice of an additional oncoproteomics analysis, and an optional preservation of your tumor cells. Deciding on which test package is right for you depends on your individual situation. This means that the most comprehensive test is not always the most suitable test for you.

That’s why you only pay a service fee in advance to cover the costs of creating the cell culture. As it makes no sense to test drugs that your oncologist cannot prescribe for you, we choose the drugs in close cooperation with your oncologist. We only finalize the test procedure after working with you and your oncologist to select the substances and methods to be tested.

In general, we can say: The more complex, larger, and advanced your tumor is, the more promising the “Henrietta Lacks” and “Mina Bissell” test procedures are. Whichever procedure you choose, however, will not in any way influence the quality of the results, which are consistently high.